This volume was supported by the Grant CNCSIS-Ideas No. 2440/2008 from the National University Research Council of Romania, awarded to university professor dr. Mircea Miclea.Worldwide, the number of individuals suffering of mental disorders is constantly increasing, while the number of certified therapists is limited.In these conditions, the traditional form of intervention for anxiety disorders should “reconsider its basic principles and forms of delivery” (Miclea, Miclea, & Ciuca, 2008, p. 131).Computer-supported/mediated psychotherapy is a recent tentative to innovate the psychotherapeutic process and match both the existent demands of the market and the new attitudes of those who seek help in the digital era.The major aim of this present volume is to identify the most important factors implied in the computer-mediated therapy of anxiety disorders, which may have significant consequences on fundamental aspects implied in the delivery of therapy in the 21st century.